* indicates correspondence, + indicates equal contribution
(Please request via email if you would like a copy of anything).
Wen, Z., Orduno, M., Liang, Z., Gong, X., Mak, M. Optimization of Vascularized Intestinal Organoid Model, Advanced Healthcare Materials, (accepted 2024).
Xiao, H., Gong, X., Mak, M. Viscosity Regulates Cell Spreading and Cell-Extracellular Matrix Interactions, The FEBS Journal, (accepted 2024).
Xiao, H., Sylla, K., Gong, X., Wilkowski, B., Rossello-Martinez, A., Jordan, S.N., Mintah, E.Y., Zheng, A., Sun, H., Herzog, E.L., Mak, M. Proteolysis and Contractility Regulate Tissue Opening and Wound Healing by Lung Fibroblasts in 3D Microenvironments, Advanced Healthcare Materials, (accepted 2024).
Chen, Y., Qian, H., Mak, M.*, Tao, Z.*, Protocol for isolating and identifying extracellular vesicles derived from human umbilical cord mesenchymal stem cells, STAR Protocols, (accepted 2024).
Benmelech, S., Le, T., McKay, M., Nam, J., Subramaniam, K., Tellez, D., Vlasak, G., Mak, M. Biophysical and Biochemical Aspects of Immune Cell – Tumor Microenvironment Interactions, Applied Physics Letters (APL) Bioengineering, (2024).
Gong, X., Wen, Z., Liang, Z., Xiao, X., Lee, S., Wright, T., Nguyen, R.Y., Rossello, A., Mak, M. Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting, (2023). Preprint: https://doi.org/10.1101/2023.10.08.561456
Gong, X., Nguyen, R., Chen, Z., Zhang, X., Mak, M. Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition, (2023). Preprint: https://doi.org/10.1101/2023.10.08.561452
Gong, X., Ogino, N., Leite, M.F., Chen, Z., Liu, R., Kruglov, E., Flores, K., Cabral, A., Mendes, G.M.M., Ehrlich, B., Mak, M. Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype, (2023). Preprint: https://doi.org/10.1101/2023.10.08.561453
Zhang, X., Shi, X., Zhang, D., Gong, X., Wen, Z., Demandel, I., Zhang, J., Rossello-Martinez, A., Chan, T.J., Mak, M. Compression drives diverse transcriptomic and phenotypic adaptations in melanoma, Proceedings of the National Academy of Sciences, (2023).
Bohringer, D.*, Bauer, A., Moravec, I., Bischof, L., Kah, D., Mark, C., Grundy, T.J., Gorlach, E., O’Neill, G.E., Budday, S., Strissel, P., Strick, R., Malandrino, A., Gerum, R., Mak, M.* , Rauch, M., Fabry, B.*, Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility, Matrix Biology, (2023).
Fu, P., Guo, Y., Luo, Y., Mak, M., Zhang, J., Xu, W., Qian, H., Tao, Z., Visualization of microRNA therapy in cancers delivered by small extracellular vesicles, Journal of Nanobiotechnology, (2023).
Zhang, J., Guo, Y., Mak, M., Tao, Z., Translational medicine for acute lung injury, Journal of Translational Medicine, (2023).
Zhuang, C., Gould, J.E., Enninful, A., Shao, S., Mak, M. Biophysical and Mechanobiological Considerations for T-cell-based Immunotherapy, Trends in Pharmacological Sciences, (2023).
Nguyen, R.Y., Cabral, A.T., Rossello-Martinez, A., Zulli, A., Gong, X., Zhang, Q., Yan, J., Mak, M. Tunable Mesoscopic Collagen Island Architectures Modulate Stem Cell Behavior, Advanced Materials, (2023).
Chan, T., Zhang, X., Mak, M. Biophysical Informatics Reveals Distinctive Phenotypic Signatures and Functional Diversity of Single Cell Lineages, Bioinformatics, (2023).
Liu, C., Nguyen, R.Y., Pizzurro, G.A., Zhang, X., Gong, X., Martinez Rossello, A., Mak, M. Self-Assembly of Mesoscale Collagen Architectures and Applications in 3D Cell Migration, Acta Biomaterialia, (2022).
Mak, M., Carlier, A., Spill, F., Malandrino, A., Long, M., Gomez-Benito, M.J. Mechanobiology and the Microenvironment: Computational and Experimental Approaches, Frontiers in Cell and Developmental Biology, (2022).
Zhang, X., Chan, T., Carbonella, J., Gong, X., Ahmed, N., Liu, C., Demandel, I., Zhang, J., Pashankar, F., Mak, M. A Microfluidic-Informatics Assay for Quantitative Physical Occlusion Measurement in Sickle Cell Disease, Lab on a Chip, (2022), Front Cover Article.
Nguyen, R.+, Xiao, H.+, Gong, X.+, Arroyo, A., Cabral, A.T., Fischer, T., Zhang, X., Robert, M.E., Ehrlich, B.E., Mak, M. Cytoskeletal Dynamics Regulates Stromal Invasion Behavior of Distinct Liver Cancer Subtypes, Communications Biology, (2022).
Liu, C., Mak, M. Fibroblast-Mediated Uncaging of Cancer Cells and Dynamic Evolution of the Physical Microenvironment, Scientific Reports, (2022).
Pizzurro, G.A.+, Liu, C.+, Bridges, K., Alexander, A.F., Huang, A., Baskaran, J., Ramseier, J., Bosenberg, M.W., Mak, M.*, Miller-Jensen, K.* 3D Model of Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-promoting Phenotype, Cancers, (2021).
Xiao, H.+, Nguyen, R.Y.+, LaRanger, R., Herzog, E.L., Mak, M. Integrated Computational and Experimental Pipeline for Quantifying Local Cell-Matrix Interactions, Scientific Reports, (2021).
Fu, P., Zhang, J., Li, H., Mak, M.*, Xu, W.*, Tao, Z.* Extracellular Vesicles as Delivery Systems at Nano-/Micro-Scale, Advanced Drug Delivery Reviews, (2021).
Zhang, X., Chan, T., Mak, M. Morphodynamic Signatures of MDA-MB-231 Single Cells and Cell Doublets Undergoing Invasion in Confined Microenvironments, Scientific Reports, (2021).
Zhang, X., Mak, M. Biophysical Informatics Approach for Quantifying Phenotypic Heterogeneity in Cancer Cell Migration in Confined Microenvironments, Bioinformatics, (2021).
Mak, M. Impact of Crosslink Heterogeneity on Extracellular Matrix Mechanics and Remodeling, Computational and Structural Biotechnology Journal, (2020).
Kumari, S., Mak, M., Poh, Y., Tohme, M., Watson, N., Melo, M., Janssen, E., Dustin, M., Geha, R., Irvine, D.J. Cytoskeletal tension actively sustains the migratory T cell synaptic contact, EMBO J., (2020).
Malandrino, A., Trepat, X., Kamm, R.D., Mak, M. Dynamic Filopodial Forces Induce Accumulation, Damage, and Plastic Remodeling of 3D Extracellular Matrices, PLOS Computational Biology, (2019).
Li, Y., Wu, Y., Liu, Y., Deng, Q., Mak, M.*, Yang, X.* Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip, Nanoscale, (2019).
Li, Y., Hu, C., Wang, P., Liu, Y., Wang, L., Pi, Q., Gong, Z., Yang, X., Mak, M.*, Wu, Y.* Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microluidic chip, Journal of Nanobiotechnology, (2019).
Apasu, J., Schuette, D. LaRanger, R., Steinle, J.A., Nguyen, L.D., Grosshans, H.K., Zhang, M., Cai, W.L., Yan, Q., Robert, M.E., Mak, M., Ehrlich, B.E. Neuronal Calcium Sensor 1 (NCS1) Promotes Motility and Metastatic Spread of Breast Cancer Cells in vitro and in vivo. The FASEB Journal, (2018).
Spill, F., Bakal, C., Mak, M.* Mechanical and Systems Biology of Cancer. Computational and Structural Biotechnology Journal, (2018).
Kim, J., Reynolds, D., Zaman, M.H.*, Mak, M.* Characterization of the Mechanical Properties of Cancer Cells in 3D Matrices in Response to Collagen Concentration and Cytoskeletal Inhibitors. Integrative Biology, (2018).
Malandrino, A.*+, Mak, M.*+, Kamm, R.D.*+, Moeendarbary, E.*+ Complex mechanics of the heterogeneous extracellular matrix in cancer. Extreme Mechanics Letters, (2018).
Li, Y., Wang, P., Hu, C., Wang, K., Chang, Q., Liu, L., Han, Z., Shao, Y., Zhai, Y., Zuo, Z., Mak, M., Gong, Z., Wu, Y. Protein corona of airborne nanoscale PM2.5 induces aberrant proliferation of human lung fibroblasts based on a 3D organotypic culture. Scientific Reports, (2018).
Li, Y., Pi, Q., Wang, P., Liu, L., Han, Z., Shao, Y., Zhai, Y., Zuo, Z., Gong, Z., Mak., M., Yang, X., Wu, Y. Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter. RSC Advances, (2017).
Mak, M.*, Anderson, S., McDonough, M., Spill, F., Kim, J., Boussommier-Calleja, A., Zaman, M. H.*, Kamm, R. D.* Integrated Analysis of Intracellular Dynamics of MenaINV Cancer Cells in a 3D Matrix. Biophysical Journal, (2017).
Arora, N., Alsous, J. I., Guggenheim, J. W., Mak, M., Munera, J., Wells, J. M., Kamm, R. D., Asada, H. H., Shvartsman, S. Y., Griffith, L. G. A process engineering approach to increase organoid yield. Development, (2017).
Mak, M., Zaman, M. H.*, Kamm, R. D.*, Kim, T. Y.* Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks. Nature Communications, (2016).
Spill, F., Andasari, V., Mak, M., Kamm, R.D.*, Zaman, M.H.* Effects of 3D Geometries on Cellular Gradient Sensing and Polarization. Physical Biology, (2015).
Mak, M.+, Spill, F.+, Kamm, R. D.*, Zaman, M. H.* Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics. Journal of Biomechanical Engineering, (2015).
Mak, M., Kim, T. Y., Zaman, M. H.*, Kamm, R. D.* Multiscale Mechanobiology: Computational models for integrating molecules to multicellular systems. Integrative Biology, (2015).
Mak, M., Kamm, R. D.*, Zaman, M. H.* Impact of dimensionality and network disruption on microrheology of Cancer Cells in 3D environments. PLoS Computational Biology, 10, e1003959, (2014).
Mak, M., Erickson, D. Mechanical decision trees for investigating and modulating single-cell cancer invasion dynamics. Lab on a Chip, 14, 964-971, (2014).
Mak, M., Erickson, D. A serial micropipette microfluidic device with applications to cancer cell repeated deformation studies. Integrative Biology, 5, 1374-1384, (2013).
Mak, M., Reinhart-King, C. A., Erickson, D. Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device. Lab on a Chip, 13(3), 340-348, (2013).
Mak, M., Reinhart-King, C. A., Erickson, D. Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics. PLoS One, 6(6), e20825, (2011).
Cordovez, B., Chung, A. J., Mak, M., Erickson, D. A novel polymer microneedle fabrication process for active fluidic delivery. Microfluidics and Nanofluidics, 10(4), 785-791, (2011).
He, J., Mak, M., Liu, Y., Tang, J. X. Counterion-dependent microrheological properties of F-actin solutions across the isotropic-nematic phase transition. Physical Review E, 78(1), 011908, (2008).